We use computational models to study the cellular mechanisms of cortical microcircuit activity and brain signals, in health and disease. We develop biophysical models of human cortical circuits that integrate unique cellular and connectivity data from human brain slices. We study how abnormalities in synaptic connections and ion channels affect information processing in cortical circuits, and identify biomarkers of the cellular changes in brain signals (LFP and EEG) to improve diagnosis of mental disorders, monitoring and treatment.
Current research projects in the lab:
Somatostatin synaptic inhibition and cortical microcircuit processing in health and depression
We use our detailed models of human cortical circuits to study the effect of reduced synaptic inhibition by somatostatin (SST) interneurons on cortical pyramidal neuron spiking and cortical processing in depression.
Biomarkers of somatostatin synaptic inhibition in cortical LFP and EEG in health and depression
We use our detailed models of human cortical circuits to identify biomarkers in cortical LFP and EEG that are signatures of reduced SST inhibition in depression.
In-silico testing synaptic modulation in cortical microcircuits by pharmacology for depression
We use our detailed models of human cortical circuits to test in-silico the effect of candidate pharmacology for treating depression (GABA positive-allosteric-modulators) on spiking activity and LFP in human cortical slices. We then characterize the effect of the pharmacology on cortical processing.