We develop biophysical models of human cortical circuits to study the effect of cellular mechanisms on cortical circuit activity and brain recordings, in health and disease. Brain function is mediated by the interplay between finely-tuned circuit connectivity and versatile cellular mechanisms with which neurons are endowed. Similarly, there is increasing evidence that brain disorders involve malfunction at the intersection of cellular and circuit mechanisms. A better understanding of how cellular mechanisms affect cortical circuit activity and the associated neural recordings will therefore enable a finer diagnosis and circuit-targeted treatment of brain disorders.
We are currently studying effect of inhibitory synaptic connectivity between dendritic-targeting interneurons (Martinotti / somatostatin) and pyramidal neurons on cortical circuit processing in health and depression. We are looking at cortical input processing, and the coupling of oscillatory activity across cortical layers. In turn, we study the signatures of the cellular effects on measurable signals of cortical circuit activity in simulated electrode probes, e.g. the spatiotemporal propagation of neuronal spiking, local field potentials and electroencephalography.