Publications

Linking reduced prefrontal microcircuit inhibition in schizophrenia to EEG biomarkers in silico

Rosanally S, Mazza F, Yao HK, Moghbel F, Seo H, Hay E

PLoS CB 2026 article

Deriving connectivity from spiking activity in detailed models of large-scale cortical microcircuits

Moghbel F, Hassan MT, Guet-McCreight A, Yao HK, Hay E

iScience 2026; 29 (1) article

Linking age changes in human cortical microcircuits to impaired brain function and EEG biomarkers

Guet-McCreight A, Tripathy SR, Sibille E, Hay E

Aging Cell 2025; 25 (1) article

Spine loss in depression impairs dendritic signal integration in human cortical microcircuit models

Yao HK, Mazza F, … Sibille E, Hay E

iScience 2025; 28(5) article

EEG biomarkers of α5-GABA positive allosteric modulators in rodents

Mazza F, Guet-McCreight A, ... Sibille E, Hay E

Biol Psychiatry GOS 2025; 5(2) article

Therapeutic dose prediction of α5-GABA receptor modulation from simulated EEG of depression severity

Guet-McCreight A, Mazza F, ... Sibille E, Hay E

PLoS CB 2024; 20(12) article

Large-scale mechanistic models of brain circuits with biophysically and morphologically detailed neurons

Dura-Bernal S, … Hay E, … Arkhipov A.

Journal of Neuroscience 2024; 44 (40) article

In-silico testing of new pharmacology for restoring inhibition and human cortical function in depression

Guet-McCreight A, ... Valiante TA, Sibille E, Hay E

Communications Biology 2024; 7, 225 article

In-silico EEG Biomarkers of reduced inhibition in human cortical microcircuits in depression

Mazza F, Guet-McCreight A, Valiante TA, Griffiths JD , Hay E

PLoS Comput Biol 2023; 19(4): e1010986 article

Age-dependent increased sag amplitude in human pyramidal neurons dampens baseline cortical activity

Guet-McCreight A, Chameh HM, Mahallati S, Wishart M, Tripathy SJ, Valiante TA, Hay E

Cerebral Cortex 2023; Volume 33, Issue 8, 15 April article

An in vitro whole-cell electrophysiology dataset of human cortical neurons

Howard D,... Hay E, Valiante TA, Tripathy SJ

GigaScience 2022 article

Reduced inhibition in depression impairs stimulus processing in human cortical microcircuits

Yao HK, Guet-McCreight A, Mazza F, ... , Valiante TA, Sibille E, Hay E

Cell Reports 2022; 38 (2) article

Orientation processing by synaptic integration across first-order tactile neurons

Hay E, Pruszynski JA

PLoS Comput Biol. 2020 Dec 2; 16 (12): e1008303 article

Multiregional integration in the brain during resting-state fMRI activity

Hay E, Ritter P, Lobaugh NJ, McIntosh AR

PLoS Comput Biol. 2017 Mar 1; 13 (3): e1005410 article

A theoretical view of the neuron as an input-output computing device

Hay E, Gidon A, London M, Segev I

Dendrites. 3rd edition, Oxford University Press. 2016, 439-464

Reconstruction and simulation of neocortical microcircuitry

Markram H, ..., Hay E, et al.

Cell. 2015 Oct 8; 163 (2): 456-92 article

Dendritic excitability and gain control in recurrent cortical microcircuits

Hay E, Segev I

Cereb Cortex. 2015 Oct; 25 (10): 3561-71 article

Preserving axosomatic spiking features despite diverse dendritic morphology

Hay E, Schurmann F, Markram H, Segev I

J Neurophysiol. 2013 Jun; 109 (12): 2972-81 article

Models of neocortical layer 5b pyramidal cells capturing a wide range of dendritic and perisomatic active properties

Hay E, Hill S, Schurmann F, Markram H, Segev I

PLoS Comput Biol. 2011 Jul; 7 (7): e1002107 article

HAY LAB

Brain Circuits

Publications

Linking reduced prefrontal microcircuit inhibition in schizophrenia to EEG biomarkers in silico

Deriving connectivity from spiking activity in detailed models of large-scale cortical microcircuits

Linking age changes in human cortical microcircuits to impaired brain function and EEG biomarkers

Spine loss in depression impairs dendritic signal integration in human cortical microcircuit models

EEG biomarkers of α5-GABA positive allosteric modulators in rodents

Therapeutic dose prediction of α5-GABA receptor modulation from simulated EEG of depression severity

Large-scale mechanistic models of brain circuits with biophysically and morphologically detailed neurons

In-silico testing of new pharmacology for restoring inhibition and human cortical function in depression

In-silico EEG Biomarkers of reduced inhibition in human cortical microcircuits in depression

Age-dependent increased sag amplitude in human pyramidal neurons dampens baseline cortical activity

An in vitro whole-cell electrophysiology dataset of human cortical neurons

Reduced inhibition in depression impairs stimulus processing in human cortical microcircuits

Orientation processing by synaptic integration across first-order tactile neurons

Multiregional integration in the brain during resting-state fMRI activity

A theoretical view of the neuron as an input-output computing device

Reconstruction and simulation of neocortical microcircuitry

Dendritic excitability and gain control in recurrent cortical microcircuits

Preserving axosomatic spiking features despite diverse dendritic morphology

Models of neocortical layer 5b pyramidal cells capturing a wide range of dendritic and perisomatic active properties

Publications

Linking reduced prefrontal microcircuit inhibition in schizophrenia to EEG biomarkers in silico

​

Deriving connectivity from spiking activity in detailed models of large-scale cortical microcircuits

​​

Linking age changes in human cortical microcircuits to impaired brain function and EEG biomarkers

Spine loss in depression impairs dendritic signal integration in human cortical microcircuit models

​

EEG biomarkers of α5-GABA positive allosteric modulators in rodents

​

Therapeutic dose prediction of α5-GABA receptor modulation from simulated EEG of depression severity

​

Large-scale mechanistic models of brain circuits with biophysically and morphologically detailed neurons

In-silico testing of new pharmacology for restoring inhibition and human cortical function in depression

​

In-silico EEG Biomarkers of reduced inhibition in human cortical microcircuits in depression

​

Age-dependent increased sag amplitude in human pyramidal neurons dampens baseline cortical activity

An in vitro whole-cell electrophysiology dataset of human cortical neurons

​

Reduced inhibition in depression impairs stimulus processing in human cortical microcircuits

​

Orientation processing by synaptic integration across first-order tactile neurons

​

Multiregional integration in the brain during resting-state fMRI activity

​

A theoretical view of the neuron as an input-output computing device

​

Reconstruction and simulation of neocortical microcircuitry

​

Dendritic excitability and gain control in recurrent cortical microcircuits

​

​​​​​​Preserving axosomatic spiking features despite diverse dendritic morphology

​

​​​​​Models of neocortical layer 5b pyramidal cells capturing a wide range of dendritic and perisomatic active properties

​

Preserving axosomatic spiking features despite diverse dendritic morphology

Models of neocortical layer 5b pyramidal cells capturing a wide range of dendritic and perisomatic active properties