Preserving spiking and EEG in detailed models of human cortical microcircuits with morphological reductions

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Guet-McCreight A, Hay E

biorxiv 2026 preprint

Linking reduced prefrontal microcircuit inhibition in schizophrenia to EEG biomarkers in silico

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Rosanally S, Mazza F, Yao HK, Moghbel F, Seo H, Hay E

PLoS CB 2026 article

Deriving connectivity from spiking activity in detailed models of large-scale cortical microcircuits

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Moghbel F, Hassan MT, Guet-McCreight A, Yao HK, Hay E

iScience 2026; 29 (1) article

Linking age changes in human cortical microcircuits to impaired brain function and EEG biomarkers

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Guet-McCreight A, Tripathy SR,  Sibille E, Hay E

Aging Cell 2025; 25 (1) article

Spine loss in depression impairs dendritic signal integration in human cortical microcircuit models

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Yao HK, Mazza F, … Sibille E, Hay E

iScience 2025; 28(5) article

EEG biomarkers of α5-GABA positive allosteric modulators in rodents

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Mazza F, Guet-McCreight A, ... Sibille E, Hay E

Biol Psychiatry GOS 2025; 5(2) article

Therapeutic dose prediction of α5-GABA receptor modulation from simulated EEG of depression severity

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Guet-McCreight A, Mazza F, ... Sibille E, Hay E

PLoS CB 2024; 20(12) article

Large-scale mechanistic models of brain circuits with biophysically and morphologically detailed neurons

 

Dura-Bernal S, … Hay E, … Arkhipov A.

Journal of Neuroscience 2024; 44 (40) article

In-silico testing of new pharmacology for restoring inhibition and human cortical function in depression

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Guet-McCreight A, ... Valiante TA, Sibille E, Hay E

Communications Biology 2024; 7, 225 article

In-silico EEG Biomarkers of reduced inhibition in human cortical microcircuits in depression

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Mazza F, Guet-McCreight A, Valiante TA, Griffiths JD , Hay E

PLoS Comput Biol 2023; 19(4): e1010986 article

Age-dependent increased sag amplitude in human pyramidal neurons dampens baseline cortical activity

 

Guet-McCreight A, Chameh HM, Mahallati S, Wishart M, Tripathy SJ, Valiante TA, Hay E

Cerebral Cortex 2023; Volume 33, Issue 8, 15 April article

An in vitro whole-cell electrophysiology dataset of human cortical neurons

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Howard D,... Hay E, Valiante TA, Tripathy SJ

GigaScience 2022 article

Reduced inhibition in depression impairs stimulus processing in human cortical microcircuits

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Yao HK, Guet-McCreight A, Mazza F, ... , Valiante TA, Sibille E, Hay E

Cell Reports 2022; 38 (2) article

Orientation processing by synaptic integration across first-order tactile neurons

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Hay E, Pruszynski JA

PLoS Comput Biol. 2020 Dec 2; 16 (12): e1008303  article

Multiregional integration in the brain during resting-state fMRI activity

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Hay E, Ritter P, Lobaugh NJ, McIntosh AR

PLoS Comput Biol. 2017 Mar 1; 13 (3): e1005410 article

A theoretical view of the neuron as an input-output computing device

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Hay E, Gidon A, London M, Segev I

Dendrites. 3rd edition, Oxford University Press. 2016, 439-464

Reconstruction and simulation of neocortical microcircuitry

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Markram H, ..., Hay E, et al.

Cell. 2015 Oct 8; 163 (2): 456-92 article

Dendritic excitability and gain control in recurrent cortical microcircuits

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Hay E, Segev I

Cereb Cortex. 2015 Oct; 25 (10): 3561-71 article

​​​​​​Preserving axosomatic spiking features despite diverse dendritic morphology

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Hay E, Schurmann F, Markram H, Segev I

J Neurophysiol. 2013 Jun; 109 (12): 2972-81 article

​​​​​Models of neocortical layer 5b pyramidal cells capturing a wide range of dendritic and perisomatic active properties

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Hay E, Hill S, Schurmann F, Markram H, Segev I

PLoS Comput Biol. 2011 Jul; 7 (7): e1002107 article